TBH I haven’t given this theory much credence in a while because of emerging evidence that bio-distribution and accumulation of LNPs and synthesized spike proteins varies greatly between individual recipients and could explain the variations in SAEs observed between lots administered at different periods, but recall last year when a Danish study (Part 2) found that 4.22% of all doses administered in the country accounted for 71% of SAEs reported in the country. These findings have once again been replicated in a comparison of Pfizer batch dependent SAE rates between Denmark and Sweden with an additional 49,749 SAE reports processed by the Danish Medical Agency this time around. This retrospective independent analysis revealed three different types of batch dependent SAE rate clusters with significantly divergent trend lines characterized by high, moderate and low SAE rates. Out of 164 batches for which the authors had complete data on doses administered 12 were administered in both countries. Out of these 12 shared batches 6 produced high SAE rates in Denmark while 9 did so in Sweden and 4 produced moderate SAE rates in Denmark while 1 did so in Sweden indicating a ‘moderate-to-strong association for mild and severe SAEs rates among the shared batches’.

https://cdn.steemitimages.com/DQmRyGgHmAPrH8Ct6GeK5eidtuYKnE8HvP4g1KaBCQ37sSH/image.png)

While the Danish batch dependent SAE rate per dose data were more heterogeneous than the Swedish data they both exhibited the highest severe SAE rate clusters in the same temporal order at the beginning of the rollout and diminishing over time.

https://cdn.steemitimages.com/DQmbRf6LP8z6Q5hLfhxJfskaeThK1D8hFQQLnrvbocuuVV8/image.png)

It’s imperative to remember that not only did the two countries have different reporting standards with the Danish medical agency instructing the public not to report ‘transient SAEs’ during the administration of batches that had moderate SAE rate clusters (green trendline), but both used passive reporting systems that likely only captured a fraction of all SAEs; the authors estimate less than 15% of SAEs were actually captured. Thus, this retrospective study like every other one does not provide conclusive evidence of the alternate hypothesis.