This is an abbreviated version of my original post on Quora

A retrospective, single-center cohort study conducted among patients with pancreatic ductal adenocarcinoma in a single Japanese medical center from April 2020 to December 2023 (n = 223), which employed both Cox Proportional Hazards Model and Propensity Score Matching, found that vaxxed patients had a significantly shorter median overall survival duration compared to unvaxxed patients 12.3 months vs. 18.6 months. The hazard ratio for mortality in the vaxxed group was 1.68 (95% CI: 1.22–2.31) compared to the unvaxxed group, indicating a higher risk of death after receiving at least one modRNA transfection. Among vaxxed patients, those who received both the primary series and booster also had a significantly shorter median overall survival duration (10.8 months) compared to those who only received one or two doses (14.5 months) suggesting a dose-dependent association with poorer survival. Even after propensity score matching, vaxxed patients still had a significantly worse overall survival duration (12.8 months) compared to unvaxxed patients (17.9 months) with a hazard ratio of 1.6. No significant interaction was found between vaxx status and other variables like age, sex, or surgical resection status. A spike-specific IgG4 analysis conducted with blood samples from a subset of patients through an enzyme-linked immunosorbent assay found that total serum IgG4 levels increased with the number of vaccinations and high IgG4 levels correlated with poorer prognosis in PC patients. Spike-specific IgG4 was also positively correlated with total IgG4.

This is not the only evidence of modRNA immunosuppression. Kenji Yamamoto notes a rise in ‘cases of shingles, monkeypox, syphilis, severe strep throat, measles, sepsis, and post-operative infections in countries administering multiple modRNA doses’ while excess deaths have exceeded 600,000 since the rollout of the COVID-19 modRNA transfections.

As I noted in a prior answer, Japan is not the only country to experience a surge in excess deaths after the COVID vaxx rollout and a global study that used WHO regional data found that COVID-19 deaths increased with Vaxx Coverage between WHO regions.

Global COVID-19 Deaths Increased with Vaxx Coverage

For both adults and children, there is a growing body of evidence for increased risks of non-COVID-19 related symptoms and diseases following the COVID vaxx primary series and/or booster.

COVID vaxx but not COVID Associated with Higher Risk of Autoimmune Disease for Children

While these are all observational studies and thus cannot make the casual inferences about the immunosupression that just happens to be associated with multiple modRNA transfections they lack one of the critical biases, found in literature purporting to find a protective effect, the healthy vaccinee bias, and serological research into long term humoral responses to the vaxx consistently finds an anti-Spike IgG4 class switch around 4–6 months after the last dose and a hampered T cell response.

Post-Vaxx subclass switch associated with increased risk of COVID-19

Cellular Immunity Hampered After Vaxx for High Risk Recipients